Welcome

We are a synthetic polymer chemistry group based in the Department of Chemistry, University of Sheffield, UK. Our research is diverse but may be loosely grouped as novel materials for therapeutics and diagnostics.

To achieve this we use a combination of "small molecule" synthesis, modern polymer synthesis, including controlled radical and ring-opening polymerizations, and in vitro and in vivo pre-clinical studies.

Current projects range from embolizing agents and trandermal drug delivery to industrial coatings. Further details can be found on our research pages or individual group member pages.

slide show image 5: Schematic of coating viruses with polyvalent diazonium polymers slide show image 1: 3D render of DNA based micelles in blood slide show image 2: FRET data for the unpacking of DNA micelles slide show image 3: 3D render of temperature responsive particles slide show image 4: Confocal microscopy image of cells treated with fluorescent polymer

News

  • 31 Jul 2019 » Kathy's paper on lidocaine delivery from electrospun patches is now online in Mol. Pharmaceutics.
  • 13 Jul 2019 » Congratulations to Dom on passing his PhD viva.
  • 15 Mar 2019 » Nora's paper on polymer-virus conjugates is now out in Bioconjugate Chem.
  • 24 Jan 2018 » Congratulations to Laila on passing her PhD viva.
  • 24 Jan 2018 » Welcome to Louisa Ejim who will be working on the Plastic - Redefining Single Use project.
  • 20 Dec 2018 » We've been awarded funding by UKRI/EPSRC to redefine single use plastic. Found out more here.
  • 07 Dec 2018 » Congratulations to Kat on passing her PhD viva.
  • 01 Oct 2018 » New starters in the group - MChem project students Elena and James, and new PhD students Josh, Sam, Ellen, Jake and Jon.
  • 01 Oct 2018 » Goodbye and good luck to Kat, who has submitted her thesis and is starting a postdoc position with Prof. Matt Gibson in Warwick
  • News archive

Recent Papers

  • "Mucoadhesive electrospun patch delivery of lidocaine to the oral mucosa and investigation of spatial distribution in tissue using MALDI mass spectrometry imaging", Mol. Pharmaceutics, 2019, Just Accepted Manuscript. [DOI]
  • "Polyvalent diazonium polymers provide efficient protection of oncolytic adenovirus Enadenotucirev from neutralising antibodies while maintaining biological activity in vitro and in vivo", Bioconjugate Chem., 2019, 30, 1244–1257. [DOI]
  • "Self-assembly of amphiphilic statistical copolymers and their aqueous rheological properties", Macromolecules, 2018, 51, 1474-1487. [DOI]
  • "Alkyl-modified oligonucleotides as intercalating vehicles for doxorubicin uptake via albumin binding", Mol. Pharmaceutics, 2018, 15, 437-446. [DOI]
  • "Control of aggregation temperatures in mixed and blended cytocompatible thermoresponsive block co-polymer nanoparticles", Soft Matter, 2017, 13, 7441-7452. [DOI]
  • Full publication list