Publications

Where copyright agreements allow a link to the published PDF may be found. Otherwise for PDF copies of any of the articles below please contact me and I will provide them where possible.

* denotes SGS as corresponding author; denotes article published open access

Peer-reviewed Journals

1. Jake G. Edmans, Craig Murdoch, Martin E. Santocildes-Romero, Paul V. Hatton, Helen E. Colley and Sebastian G. Spain; "Incorporation of Lysozyme into a Mucoadhesive Electrospun Patch for Rapid Protein Delivery to the Oral Mucosa", Mat. Sci. Eng. C., 2020, In Press. [DOI] [Summary]

2. Katharina H. Clitherow, Craig Murdoch, Sebastian G. Spain, Anne Mette Handler, Helen E. Colley, Mai Bay Stie, Hanne Mørck Nielsen, Christian Janfelt, Paul V. Hatton and Jette Jacobsen; "Mucoadhesive electrospun patch delivery of lidocaine to the oral mucosa and investigation of spatial distribution in tissue using MALDI mass spectrometry imaging", Mol. Pharmaceutics, 2019, 16, 3948-3956. [DOI] [Summary] [PDF]

3. Nora Francini, Daniel Cochrane, Sam Illingworth, Laura Purdie, Giuseppe Mantovani, Kerry Fisher, Leonard W. Seymour, Sebastian G. Spain* and Cameron Alexander; "Polyvalent diazonium polymers provide efficient protection of oncolytic adenovirus Enadenotucirev from neutralising antibodies while maintaining biological activity in vitro and in vivo", Bioconjugate Chem., 2019, 30, 1244–1257. [DOI] [Summary]

4. Thomas J. Neal, Deborah L. Beattie, Sarah J. Byard, Gregory N. Smith, Martin W. Murray, Neal S. J. Williams, Simon N. Emmett, Steven P. Armes, Sebastian G. Spain* and Oleksandr O. Mykhaylyk; "Self-assembly of amphiphilic statistical copolymers and their aqueous rheological properties", Macromolecules, 2018, 51, 1474-1487. [DOI] [Summary]

5. Laura Purdie, Cameron Alexander, Sebastian G. Spain* and Johannes P. Magnusson; "Alkyl-modified oligonucleotides as intercalating vehicles for doxorubicin uptake via albumin binding", Mol. Pharmaceutics, 2018, 15, 437-446. [DOI] [Summary]

6. Ruggero Foralosso, Lee Moir, Francesca Mastrotto, Luana Sasso, Aleksandra Tchoryk, Amjad Selo, Anna Grabowska, Marianne B. Ashford, Jonathan Aylott, Paul R. Gellert, Sebastian G. Spain and Cameron Alexander; "Control of aggregation temperatures in mixed and blended cytocompatible thermoresponsive block co-polymer nanoparticles", Soft Matter, 2017, 13, 7441-7452. [DOI] [Summary] [PDF]

7. Laura Shallcross, Kevin Roche, Caroline J. Wilcock, Kenneth J. Stanton, Thomas Swift, Stephen Rimmer, Paul V. Hatton and Sebastian G. Spain*; "The effect of hyperbranched poly(acrylic acid)s on the morphology and size of precipitated nanoscale (fluor)hydroxyapatite.", J. Mater. Chem. B., 2017, 5, 6027-6033. [DOI] [Summary] [PDF]

8. Laura Purdie, Cameron Alexander, Sebastian G. Spain* and Johannes P. Magnusson; "Influence of polymer size on uptake and cytotoxicity of doxorubicin-loaded DNA–PEG conjugates", Bioconjugate Chem., 2016, 27, 1244-1252. [DOI] [Summary]

9. Andrea D. Goncalves, Cameron Alexander, Clive J. Roberts, Sebastian G. Spain, Shahid Uddin and Stephanie Allen; "The effect of protein concentration on the viscosity of a recombinant albumin solution formulation", RSC Advances, 2016, 6, 15143-15154. [DOI] [Summary] [PDF]

10. Giovanna Sicilia, Adrienne L. Davis, Sebastian G. Spain, Johannes P. Magnusson, Nathan Boase, Kristofer J. Thurecht and Cameron Alexander; "Synthesis of 19F Nucleic Acid–Polymer Conjugates as Real-Time MRI Probes of Biorecognition.", Polym. Chem., 2016, 7, 2180-2191. [DOI] [Summary] [PDF]

11. Vanessa Loczenski Rose, Saif Shubber, S. Sajeesh, Sebastian G. Spain, Sanyogitta Puri, Stephanie Allen, Dong-Ki Lee, G. Sebastiaan Winkler and Giuseppe Mantovani; "Phosphonium polymethacrylates for siRNA delivery - effect of polymer and RNA structural parameters on polyplex assembly and gene knockdown.", Biomacromolecules, 2015, 16, 3480-3490. [DOI] [Summary]

12. Nora Francini, Laura Purdie, Cameron Alexander, Giuseppe Mantovani and Sebastian G. Spain*; "Multifunctional poly[N-(2-hydroxypropyl)methacrylamide] copolymers via post-polymerization modification and sequential thiol–ene chemistry", Macromolecules, 2015, 48, 2857-2863. [DOI] [Summary]

13. Daniel E. Mitchell, Mary Lilliman, Sebastian G. Spain and Matthew I. Gibson; "Quantitative study on the antifreeze protein mimetic ice growth inhibition properties of poly(ampholytes) derived from vinyl-based polymers", Biomater. Sci., 2014, 2, 1781-1795. [DOI] [Summary] [PDF]

14. E. Peter Magennis, Francisco Fernández-Trillo, Cheng Sui, Sebastian G. Spain, David J. Bradshaw, David Churchley, Giuseppe Mantovani, Klaus Winzer and Cameron Alexander; "Bacteria-instructed synthesis of polymers for self-selective microbial binding and labelling", Nature Mater., 2014, 13, 748-755. [DOI] [Summary]

15. Johannes P. Magnusson, Francisco Fernández-Trillo, Giovanna Sicilia, Sebastian G. Spain* and Cameron Alexander; "Programmed assembly of polymer-DNA conjugate nanoparticles with optical readout and sequence-specific activation of biorecognition", Nanoscale, 2014, 6, 2368-2374. [DOI] [Summary] [PDF]

16. Giovanna Sicilia, Christine Grainger-Boultby, Nora Francini, Johannes P. Magnusson, Aram O. Saeed, Francisco Fernández-Trillo, Sebastian G. Spain* and Cameron Alexander; "Programmable polymer-DNA hydrogels with dual input and multiscale responses", Biomat. Sci., 2014, 2, 203-211. [DOI] [Summary] [PDF]

17. Teresa Matini, Nora Francini, Anna Battocchio, Sebastian G. Spain, Giuseppe Mantovani, Maria J. Vicent, Joaquin Sanchis, Elena Gallon, Francesca Mastrotto, Stefano Salmaso, Paolo Caliceti and Cameron Alexander; "Synthesis and characterization of variable conformation pH responsive block co-polymers for nucleic acid delivery and targeted cell entry", Polym. Chem., 2014, 5, 1626-1636. [DOI] [Summary] [PDF]

18. Gokcen Yasayan, Johannes P. Magnusson, Giovanna Sicilia, Sebastian G. Spain, Stephanie Allen, Martyn C. Davies, and Cameron Alexander; "Multi-modal switching in responsive DNA block co-polymer conjugates", Phys. Chem. Chem. Phys., 2013, 15, 16263-16274. [DOI] [Summary] [PDF]

19. Samer R. Abulateefeh, Sebastian G. Spain, Kristofer J. Thurecht, Jonathan W. Aylott, Weng C. Chan, Martin C. Garnett and Cameron Alexander; "Enhanced uptake of nanoparticle drug carriers via a thermoresponsive shell enhances cytotoxicity in a cancer cell line", Biomater. Sci., 2013, 1, 434-442. [DOI] [Summary] [PDF]

20. Gokcen Yasayan, Martin Redhead, Johannes P. Magnusson, Sebastian G. Spain, Stephanie Allen, Martyn C. Davies, Cameron Alexander and Francisco Fernandez-Trillo; "Well-defined Polymeric Vesicles with High Stability and Modulation of Cell Uptake by a Simple Coating Protocol", Polym. Chem., 2012, 3, 2596-2604. [DOI] [Summary] [PDF]

21. Samer R. Abulateefeh, Sebastian G. Spain, Jonathan W. Aylott et al.; "Thermoresponsive colloids in cancer therapy", Macromol. Biosci., 2011, 11, 1722-1734. [DOI] [Summary]

22. Sebastian G. Spain* and Neil R. Cameron; "The binding of polyvalent galactosides to the lectin Ricinus communis agglutinin 120 (RCA120) - an ITC and SPR study", Polym. Chem., 2011, 2, 1552-1560. [DOI] [Summary] [PDF]

23. Sebastian G. Spain and Neil R. Cameron; "A spoonful of sugar - the application of glycopolymers in therapeutics", Polym. Chem., 2011, 2, 60-68. [DOI] [Summary] [PDF]

24. Matthew I. Gibson, Carl A. Barker, Sebastian G. Spain, Luca Albertin and Neil R. Cameron; "Inhibition of ice crystal growth by synthetic glycopolymers - implications for the rational design of antifreeze glycoprotein mimics", Biomacromolecules, 2009, 10, 328-333. [DOI] [Summary]

25. Neil R. Cameron, Sebastian G. Spain, James A. Kingham, Stefan Weck, Luca Albertin, Carl A. Barker, Guiseppe Battaglia, Thomas Smart, and Adam Blanazs; "Synthesis of well-defined glycopolymers and some studies of their aqueous solution behaviour", Faraday Discuss., 2008, 139, 359-368. [DOI] [Summary] [PDF]

26. Sebastian G. Spain, Matthew I. Gibson and Neil R. Cameron; "Recent Advances in the Synthesis of Well-defined Glycopolymers", J. Polym. Sci. Part A Polym. Chem., 2007, 45, 2059-2072. [DOI] [Summary]

27. Sebastian G. Spain, Luca Albertin and Neil R. Cameron; "Facile in Situ Preparation of Biologically Active Multivalent Glyconanoparticles", Chem. Commun., 2006, 4198-4200. [DOI] [Summary] [PDF]

Book Chapters

1. Sebastian G. Spain, Gokcen Yasayan, Mahmoud Soliman, Felicity Heath, Aram O. Saeed and Cameron Alexander; "Nanoparticles of Nucleic Acid Delivery" in Comprehensive Biomaterials, 2011, vol. 4, 389-410.