Publications

Where copyright agreements allow a link to the published PDF may be found. Otherwise for PDF copies of any of the articles below please contact me and I will provide them where possible.

* denotes SGS as corresponding author; denotes article published open access

Peer-reviewed Journals

1. Katharina H. Clitherow, Craig Murdoch, Sebastian G. Spain, Anne Mette Handler, Helen E. Colley, Mai Bay Stie, Hanne Mørck Nielsen, Christian Janfelt, Paul V. Hatton and Jette Jacobsen; "Mucoadhesive electrospun patch delivery of lidocaine to the oral mucosa and investigation of spatial distribution in tissue using MALDI mass spectrometry imaging", Mol. Pharmaceutics, 2019, 16, 3948-3956. [DOI] [Summary] [PDF]

2. Nora Francini, Daniel Cochrane, Sam Illingworth, Laura Purdie, Giuseppe Mantovani, Kerry Fisher, Leonard W. Seymour, Sebastian G. Spain* and Cameron Alexander; "Polyvalent diazonium polymers provide efficient protection of oncolytic adenovirus Enadenotucirev from neutralising antibodies while maintaining biological activity in vitro and in vivo", Bioconjugate Chem., 2019, 30, 1244–1257. [DOI] [Summary]

3. Thomas J. Neal, Deborah L. Beattie, Sarah J. Byard, Gregory N. Smith, Martin W. Murray, Neal S. J. Williams, Simon N. Emmett, Steven P. Armes, Sebastian G. Spain* and Oleksandr O. Mykhaylyk; "Self-assembly of amphiphilic statistical copolymers and their aqueous rheological properties", Macromolecules, 2018, 51, 1474-1487. [DOI] [Summary]

4. Laura Purdie, Cameron Alexander, Sebastian G. Spain* and Johannes P. Magnusson; "Alkyl-modified oligonucleotides as intercalating vehicles for doxorubicin uptake via albumin binding", Mol. Pharmaceutics, 2018, 15, 437-446. [DOI] [Summary]

5. Ruggero Foralosso, Lee Moir, Francesca Mastrotto, Luana Sasso, Aleksandra Tchoryk, Amjad Selo, Anna Grabowska, Marianne B. Ashford, Jonathan Aylott, Paul R. Gellert, Sebastian G. Spain and Cameron Alexander; "Control of aggregation temperatures in mixed and blended cytocompatible thermoresponsive block co-polymer nanoparticles", Soft Matter, 2017, 13, 7441-7452. [DOI] [Summary] [PDF]

6. Laura Shallcross, Kevin Roche, Caroline J. Wilcock, Kenneth J. Stanton, Thomas Swift, Stephen Rimmer, Paul V. Hatton and Sebastian G. Spain*; "The effect of hyperbranched poly(acrylic acid)s on the morphology and size of precipitated nanoscale (fluor)hydroxyapatite.", J. Mater. Chem. B., 2017, 5, 6027-6033. [DOI] [Summary] [PDF]

7. Laura Purdie, Cameron Alexander, Sebastian G. Spain* and Johannes P. Magnusson; "Influence of polymer size on uptake and cytotoxicity of doxorubicin-loaded DNA–PEG conjugates", Bioconjugate Chem., 2016, 27, 1244-1252. [DOI] [Summary]

8. Andrea D. Goncalves, Cameron Alexander, Clive J. Roberts, Sebastian G. Spain, Shahid Uddin and Stephanie Allen; "The effect of protein concentration on the viscosity of a recombinant albumin solution formulation", RSC Advances, 2016, 6, 15143-15154. [DOI] [Summary] [PDF]

9. Giovanna Sicilia, Adrienne L. Davis, Sebastian G. Spain, Johannes P. Magnusson, Nathan Boase, Kristofer J. Thurecht and Cameron Alexander; "Synthesis of 19F Nucleic Acid–Polymer Conjugates as Real-Time MRI Probes of Biorecognition.", Polym. Chem., 2016, 7, 2180-2191. [DOI] [Summary] [PDF]

10. Vanessa Loczenski Rose, Saif Shubber, S. Sajeesh, Sebastian G. Spain, Sanyogitta Puri, Stephanie Allen, Dong-Ki Lee, G. Sebastiaan Winkler and Giuseppe Mantovani; "Phosphonium polymethacrylates for siRNA delivery - effect of polymer and RNA structural parameters on polyplex assembly and gene knockdown.", Biomacromolecules, 2015, 16, 3480-3490. [DOI] [Summary]

11. Nora Francini, Laura Purdie, Cameron Alexander, Giuseppe Mantovani and Sebastian G. Spain*; "Multifunctional poly[N-(2-hydroxypropyl)methacrylamide] copolymers via post-polymerization modification and sequential thiol–ene chemistry", Macromolecules, 2015, 48, 2857-2863. [DOI] [Summary]

12. Daniel E. Mitchell, Mary Lilliman, Sebastian G. Spain and Matthew I. Gibson; "Quantitative study on the antifreeze protein mimetic ice growth inhibition properties of poly(ampholytes) derived from vinyl-based polymers", Biomater. Sci., 2014, 2, 1781-1795. [DOI] [Summary] [PDF]

13. E. Peter Magennis, Francisco Fernández-Trillo, Cheng Sui, Sebastian G. Spain, David J. Bradshaw, David Churchley, Giuseppe Mantovani, Klaus Winzer and Cameron Alexander; "Bacteria-instructed synthesis of polymers for self-selective microbial binding and labelling", Nature Mater., 2014, 13, 748-755. [DOI] [Summary]

14. Johannes P. Magnusson, Francisco Fernández-Trillo, Giovanna Sicilia, Sebastian G. Spain* and Cameron Alexander; "Programmed assembly of polymer-DNA conjugate nanoparticles with optical readout and sequence-specific activation of biorecognition", Nanoscale, 2014, 6, 2368-2374. [DOI] [Summary] [PDF]

15. Giovanna Sicilia, Christine Grainger-Boultby, Nora Francini, Johannes P. Magnusson, Aram O. Saeed, Francisco Fernández-Trillo, Sebastian G. Spain* and Cameron Alexander; "Programmable polymer-DNA hydrogels with dual input and multiscale responses", Biomat. Sci., 2014, 2, 203-211. [DOI] [Summary] [PDF]

16. Teresa Matini, Nora Francini, Anna Battocchio, Sebastian G. Spain, Giuseppe Mantovani, Maria J. Vicent, Joaquin Sanchis, Elena Gallon, Francesca Mastrotto, Stefano Salmaso, Paolo Caliceti and Cameron Alexander; "Synthesis and characterization of variable conformation pH responsive block co-polymers for nucleic acid delivery and targeted cell entry", Polym. Chem., 2014, 5, 1626-1636. [DOI] [Summary] [PDF]

17. Gokcen Yasayan, Johannes P. Magnusson, Giovanna Sicilia, Sebastian G. Spain, Stephanie Allen, Martyn C. Davies, and Cameron Alexander; "Multi-modal switching in responsive DNA block co-polymer conjugates", Phys. Chem. Chem. Phys., 2013, 15, 16263-16274. [DOI] [Summary] [PDF]

18. Samer R. Abulateefeh, Sebastian G. Spain, Kristofer J. Thurecht, Jonathan W. Aylott, Weng C. Chan, Martin C. Garnett and Cameron Alexander; "Enhanced uptake of nanoparticle drug carriers via a thermoresponsive shell enhances cytotoxicity in a cancer cell line", Biomater. Sci., 2013, 1, 434-442. [DOI] [Summary] [PDF]

19. Gokcen Yasayan, Martin Redhead, Johannes P. Magnusson, Sebastian G. Spain, Stephanie Allen, Martyn C. Davies, Cameron Alexander and Francisco Fernandez-Trillo; "Well-defined Polymeric Vesicles with High Stability and Modulation of Cell Uptake by a Simple Coating Protocol", Polym. Chem., 2012, 3, 2596-2604. [DOI] [Summary] [PDF]

20. Samer R. Abulateefeh, Sebastian G. Spain, Jonathan W. Aylott et al.; "Thermoresponsive colloids in cancer therapy", Macromol. Biosci., 2011, 11, 1722-1734. [DOI] [Summary]

21. Sebastian G. Spain* and Neil R. Cameron; "The binding of polyvalent galactosides to the lectin Ricinus communis agglutinin 120 (RCA120) - an ITC and SPR study", Polym. Chem., 2011, 2, 1552-1560. [DOI] [Summary] [PDF]

22. Sebastian G. Spain and Neil R. Cameron; "A spoonful of sugar - the application of glycopolymers in therapeutics", Polym. Chem., 2011, 2, 60-68. [DOI] [Summary] [PDF]

23. Matthew I. Gibson, Carl A. Barker, Sebastian G. Spain, Luca Albertin and Neil R. Cameron; "Inhibition of ice crystal growth by synthetic glycopolymers - implications for the rational design of antifreeze glycoprotein mimics", Biomacromolecules, 2009, 10, 328-333. [DOI] [Summary]

24. Neil R. Cameron, Sebastian G. Spain, James A. Kingham, Stefan Weck, Luca Albertin, Carl A. Barker, Guiseppe Battaglia, Thomas Smart, and Adam Blanazs; "Synthesis of well-defined glycopolymers and some studies of their aqueous solution behaviour", Faraday Discuss., 2008, 139, 359-368. [DOI] [Summary] [PDF]

25. Sebastian G. Spain, Matthew I. Gibson and Neil R. Cameron; "Recent Advances in the Synthesis of Well-defined Glycopolymers", J. Polym. Sci. Part A Polym. Chem., 2007, 45, 2059-2072. [DOI] [Summary]

26. Sebastian G. Spain, Luca Albertin and Neil R. Cameron; "Facile in Situ Preparation of Biologically Active Multivalent Glyconanoparticles", Chem. Commun., 2006, 4198-4200. [DOI] [Summary] [PDF]

Book Chapters

1. Sebastian G. Spain, Gokcen Yasayan, Mahmoud Soliman, Felicity Heath, Aram O. Saeed and Cameron Alexander; "Nanoparticles of Nucleic Acid Delivery" in Comprehensive Biomaterials, 2011, vol. 4, 389-410.